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10.1101/cshperspect.a028936 56 LeathemA.Ortiz-CerdaT.DennisJ

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However, Se supplementation was not observed to exert a stronger effect than placebo in reducing TPOAb concentrations or the prevalence of TPOAb positivity during the course of pregnancy

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A 2015 review in the Journal of Clinical Endocrinology confirming that GHRH analogs combined with ghrelin-pathway agonists produce a synergistic GH secretory response that exceeds additive effects when either compound is used alone provides the mechanistic basis for why combination therapy is the standard in supervised clinical settings